Value of Glypican-1 Expression in Pleural Epithelioid Mesothelioma, Adenocarcinoma and Squamous Cell Carcinoma of the Lung

Background: Distinguishing between pleural epithelioid mesothelioma, lung adenocarcinoma, and poorly differentiated squamous cell carcinoma (SCC) is a challenge in some cases. A panel of markers has been recommended by the International Mesothelioma Interest Group (IMIG) guideline to differentiate mesothelioma from adenocarcinoma SCC. However, use novel highly specific immunohistochemical (IHC) still required. Objectives: This study aimed evaluate glypican-1 (GPC1) expression SCC, correlating its with known clinicopathological parameters clarify diagnostic prognostic value.Methods: included seventy specimens designated as 20 cases 30 GPC1 was evaluated using immunohistochemistry (IHC). The data analyzed statistically SPSS software 25. correlated different clinicopathologic Chi-square test. conducted according local Ethical Committee regulations. Results: detected positive reactivity all (100%) which increased large-sized, high grade, advanced stage tumors, presence lymph node metastasis (LNM). In contrast, absent about 93% cases, only 2 exhibited weak focal expression. Conclusion: Our findings demonstrated that upregulated pulmonary SCC; tumors more biological behavior.